Salaam-e-ishq is the story of 6 groups of people. From different parts of the world. From different walks of life. Ignorant about each other's existence, but who end up being brought together by destiny, fate and LOVE…
Tehzeeb (Vidya Balan) wakes up in the morning to find a small diamond pendant by her bedside. An anniversary gift from her very romantic husband Ashutosh (John Abraham). They had eloped and got married two years ago. Struggling like all young married couples in Bombay they work in media - at a news channel. She is a field reporter and he is a film editor. Completely crazy about each other they find it quite difficult to keep their hands off each other. But things are going to change… Because Tehzeeb is going to be involved in a tragic accident that will change everything… That will put Ashu's love and devotion to the ultimate test.

Raju taxiwala (Govinda) wakes up in the morning and gets into his colorful Delhi taxi. He drives from his home in Chandni Chowk to the New Delhi International Airport. Like he has for the last 15 years. He joins the long queue at the airport. Like has for the last 15 years. Unlike the other taxi drivers he does not complain about the ever-increasing queue. He hasn't… even once for the last 15 years. Because he enjoys watching the doors of the New Delhi International Airport. Opening and closing. He enjoys watching the passengers coming out. Hoping that among them will be HER… His blonde dream girl (Stephanie) … the girl that he has waited for the last 15 years… But things are going to change… Because his dream girl does come. From those very doors… The only problem is that Stephanie has come looking for Rohit Chaddha - her boyfriend…

Vinay Malhotra (Anil Kapoor) wakes up in his picture perfect suburban London home every morning. He is cared for by his picture perfect wife Seema (Juhi Chawla), and his picture perfect daughters kiss him goodbye. He goes to his picture perfect London PR job and returns to his picture perfect wife, daughters and home. But things are going to change… Because Vinay Malhotra meets the not so perfect Anjali (Anjana). Unconventional, over-confident and extremely determined, Anjali comes from a world that Vinay only dreams off. A world where the very modern single girl living in London gets what she wants… And Anjali wants Vinay Malhotra…